Simon N. Powell
Simon N. Powell | |
|---|---|
| Born | February 13, 1955 Manchester, England |
| Nationality | British/Permanent Resident in the U.S. |
| Alma mater | Oxford University, U.K. (B.A.) 1976, The University of London, U.K. (M.B.B.S.) 1981, The University of London, U.K. (Ph.D.) 1991 |
| Spouse | Naomi Joshi |
| Scientific career | |
| Fields | Radiation Oncology and Breast Cancer Research |
| Institutions | Sloan Kettering Institute at Memorial Sloan Kettering Cancer Center |
| Website | The Simon Powell Lab |
Simon N. Powell (born February 1955) is a British cancer researcher and radiation oncologist residing in New York City.
Biography
[edit]Powell was born on February 13, 1955, in Manchester, England. Powell received the Bachelor of Medicine, Bachelor of Surgery in 1981 from the University of London and went on to complete his Ph.D. there in 1991, holding residencies at Whittington Hospital and Hammersmith Hospital in London[1] and a fellowship at the Royal Marsden Hospital before being recruited and settling in America.[2][3]
Career
[edit]Powell held a fellowship at Harvard Medical School in 1991,[4] becoming an instructor in 1992, and associate professor of radiation oncology in 1998. He then became clinical director of the Gillette Center for Women's Cancers,[5] co-leader of the Harvard Breast Cancer Research Program, and leader of the DNA Repair/Radiation Biology Program.[4] From 2004 to 2008 he served as professor and head of Radiation therapy/radiation oncology at the Washington University School of Medicine in St. Louis.[3][5]
In 2008, Powell moved to New York to join Memorial Sloan Kettering Cancer Center and become the Chair of the Department of Radiation Oncology in Memorial Hospital[6] with a joint appointment in Sloan Kettering Institute's Molecular Biology Program.[7] He was also appointed to the faculties of the Gerstner Sloan Kettering Graduate School of Biomedical Science[8] and Weill Cornell Graduate School of Medical Sciences.[9][10] He also holds the Enid A. Haupt Chair in Radiation Oncology at the Center.[11] His career has centered on understanding DNA repair alterations in cancer and how they can be used for the basis of selective cancer therapies. His clinical expertise is in the treatment of breast cancer.[2]
Memberships and significant positions
[edit]- Fellow of the Royal College of Radiologists of the United Kingdom[12]
- Associate editor, International Journal of Cancer for eight years[3]
- Associate editor, Radiation Research for 5 years[13]
- Editorial board of the Journal of Cancer Biology and Therapy (now the International Journal of Cancer)[14]
- Member, American Association for Cancer Research[15]
- Member, Radiation Research Society[16]
Awards
[edit]- Fellow of the American Society for Radiation Oncology (FASTRO) 2014[17]
- European Society for Theapeutic Radiology and Oncology (E.S.T.R.O.) Varian Award (1990)[18]
Selected publications
[edit]- Powell, Simon N.; Defrank, Jeffrey S.; Connell, Paul; Eogan, Maeve; Preffer, Frederic; Dombkowski, David; Tang, Wei; Friend, Stephen (1995). "Differential sensitivity of p53(-) and p53(+) cells to caffeine-induced radiosensitization and override of G2 delay". Cancer Research. 55 (8): 1643–8. PMID 7712468.
- Mekeel, Kristin L; Tang, Wei; Kachnic, Lisa A; Luo, Chen-Mei; Defrank, Jeffrey S; Powell, Simon N (1997). "Inactivation of p53 results in high rates of homologous recombination". Oncogene. 14 (15): 1847–57. doi:10.1038/sj.onc.1201143. PMID 9150391. S2CID 25122282.
- Xia, F.; Taghian, D.G.; DeFrank, J.S.; Zeng, Z.C.; Willers, H.; Iliakis, G.; Powell, S.N. (2001). "Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining". Proceedings of the National Academy of Sciences. 98 (15): 8644–9. Bibcode:2001PNAS...98.8644X. doi:10.1073/pnas.151253498. PMC 37489. PMID 11447276.
- Zhang, J; Willers, H; Feng, Z; Ghosh, JC; Kim, S; Weaver, DT; Chung, JH; Powell, SN; Xia, F (2004). "Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair". Molecular and Cellular Biology. 24 (2): 708–18. doi:10.1128/MCB.24.2.708-718.2004. PMC 343805. PMID 14701743.
- Romanova, Larisa Y; Willers, Henning; Blagosklonny, Mikhail V; Powell, Simon N (2004). "The interaction of p53 with replication protein a mediates suppression of homologous recombination". Oncogene. 23 (56): 9025–33. doi:10.1038/sj.onc.1207982. PMID 15489903.
- Litman, Rachel; Peng, Min; Jin, Zhe; Zhang, Fan; Zhang, Junran; Powell, Simon; Andreassen, Paul R.; Cantor, Sharon B. (2005). "BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ". Cancer Cell. 8 (3): 255–65. doi:10.1016/j.ccr.2005.08.004. PMID 16153896.
- Zhang, Junran; Ma, Zhefu; Treszezamsky, Alejandro; Powell, Simon N (2005). "MDC1 interacts with Rad51 and facilitates homologous recombination". Nature Structural & Molecular Biology. 12 (10): 902–9. doi:10.1038/nsmb991. PMID 16186822. S2CID 24097999.
- Feng, Z.; Scott, S. P.; Bussen, W.; Sharma, G. G.; Guo, G.; Pandita, T. K.; Powell, S. N. (2010). "Rad52 inactivation is synthetically lethal with BRCA2 deficiency". Proceedings of the National Academy of Sciences. 108 (2): 686–91. doi:10.1073/pnas.1010959107. PMC 3021033. PMID 21148102.
- Bott, Matthew; Brevet, Marie; Taylor, Barry S; Shimizu, Shigeki; Ito, Tatsuo; Wang, Lu; Creaney, Jenette; Lake, Richard A; et al. (2011). "The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma". Nature Genetics. 43 (7): 668–72. doi:10.1038/ng.855. PMC 4643098. PMID 21642991.
- Riaz, N; Blecua, P; Lim, RS; Shen, R; Higginson, DS; Weinhold, N; Norton, L; Weigelt, B; Powell, SN; Reis-Filho, JS (11 October 2017). "Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes". Nature Communications. 8 (1): 857. Bibcode:2017NatCo...8..857R. doi:10.1038/s41467-017-00921-w. PMC 5636842. PMID 29021619.
- Bakhoum, SF; Ngo, B; Laughney, AM; Cavallo, JA; Murphy, CJ; Ly, P; Shah, P; Sriram, RK; Watkins, TBK; Taunk, NK; Duran, M; Pauli, C; Shaw, C; Chadalavada, K; Rajasekhar, VK; Genovese, G; Venkatesan, S; Birkbak, NJ; McGranahan, N; Lundquist, M; LaPlant, Q; Healey, JH; Elemento, O; Chung, CH; Lee, NY; Imielenski, M; Nanjangud, G; Pe'er, D; Cleveland, DW; Powell, SN; Lammerding, J; Swanton, C; Cantley, LC (25 January 2018). "Chromosomal instability drives metastasis through a cytosolic DNA response". Nature. 553 (7689): 467–472. Bibcode:2018Natur.553..467B. doi:10.1038/nature25432. PMC 5785464. PMID 29342134.
References
[edit]- ^ "Dr. Simon Powell - Radiation Oncology - New York, NY". www.castleconnolly.com. Retrieved 2018-10-09.
- ^ a b Suit, Herman D.; Loeffler, Jay S. (2011-02-04). Evolution of Radiation Oncology at Massachusetts General Hospital. Springer Science & Business Media. p. 141. ISBN 9781441967442.
- ^ a b c "Simon Powell to Lead Department of Radiation Oncology". Barnes Jewish Hospital. Washington University School of Medicine in St. Louis. July 13, 2004. Archived from the original on September 5, 2015. Retrieved January 9, 2013
- ^ a b "Simon Powell Moving to Head Radiation Oncology at Washington University". Cancer Biology & Therapy. 3 (8): 699–707. 2004-05-07. doi:10.4161/cbt.3.8.1108. ISSN 1538-4047.
- ^ a b "Awards, Appointments, Announcements". J Natl Cancer Inst. 96 (16): 1203. 2004. doi:10.1093/jnci/96.16.1203.
- ^ Bogdanich, Walt (Jan 14, 2013). "Radiation Bills Raise Question of Supervision". The New York Times. Retrieved Feb 25, 2010.
- ^ "Simon Powell Named Chair of Radiation Oncology". 2015-12-31. Archived from the original on December 31, 2015. Retrieved January 10, 2013
- ^ "Faculty | Gerstner Sloan Kettering Graduate School of Biomedical Sciences". www.sloankettering.edu. Retrieved 5 October 2018.
- ^ "Weill Cornell Graduate School of Medical Sciences, Cornell University, Our Faculty". Archived from the original on December 22, 2012.
- ^ "Biochemistry & Structural Biology, Cell & Developmental Biology, and Molecular Biology Overview". Weill Cornell Graduate School of Medical Sciences, Cornell University. Archived from the original on November 18, 2012.
- ^ "Simon N. Powell | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 2018-10-06.
- ^ "Simon N. Powell, M.D., Ph.D., Department of Radiation Oncology, Chairman". Washington University School of Medicine. Archived from the original on March 4, 2016. Retrieved Jan 14, 2013.
- ^ Radiation Research Society News Annual Report - Radiation Research 2000 Retrieved January 11, 2013
- ^ "Landes Bioscience, Cancer Biology & Therapy Journal, Editorial Board". Archived from the original on October 1, 2014.
- ^ Lok, BH; Powell, SN (2012). "Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement". Clinical Cancer Research. 18 (23). American Association for Cancer Research: 6400–6406. doi:10.1158/1078-0432.CCR-11-3150. PMC 3513650. PMID 23071261. P. 7
- ^ "56th Annual Meeting, Radiation Research Society, Oceans of Opportunity" (PDF). Synthetic Lethality and Repair Targeting: New Opportunities for Treatment. Radiation Research Society. Archived from the original (PDF) on May 15, 2012. Retrieved Jan 14, 2013.
- ^ "Fellow Recipients - American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO)". ASTRO. Retrieved 2018-10-06.
- ^ "ESTRO - Varian Research Award". Clonal variation of DNA repair in a human glioma cell line. Institute of Cancer Research, Sutton, Surrey, UK. Archived from the original on March 30, 2012. Retrieved Jan 14, 2013.
External links
[edit]- Publications: Simon N. Powell's Publications
- Pubmed: Simon N. Powell's Journal Articles
- An Interview with Simon Powell